The role and pharmacological properties of the P2X7 receptor in neuropathic pain
| Autor: | Zeng-Xu Liu, Wen-jun Zhang, Zheng-Ming Zhu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nervous system Purinergic P2X Receptor Antagonists Lidocaine medicine.medical_treatment Bioinformatics Targeted therapy 03 medical and health sciences Adenosine Triphosphate 0302 clinical medicine medicine Animals Humans Inflammation business.industry General Neuroscience Antagonist Brain Nerve injury 030104 developmental biology medicine.anatomical_structure Neuropathic pain Morphine Neuralgia Microglia Receptors Purinergic P2X7 medicine.symptom business 030217 neurology & neurosurgery Ion channel linked receptors Signal Transduction medicine.drug |
| Zdroj: | Brain Research Bulletin. 155:19-28 |
| ISSN: | 0361-9230 |
| DOI: | 10.1016/j.brainresbull.2019.11.006 |
| Popis: | Neuropathic Pain (NPP) is caused by direct or indirect damage to the nervous system and is a common symptom of many diseases. Clinically, drugs are usually used to suppress pain, such as (lidocaine, morphine, etc.), but the effect is short-lived, poor analgesia, and there are certain dependence and side effects. Therefore, the investigation of the treatment of NPP has become an urgent problem in medical, attracting a lot of research attention. P2X7 is dependent on Adenosine triphosphate (ATP) ion channel receptors and has dual functions for the development of nerve damage and pain. In this review, we explored the link between the P2X7 receptor (P2X7R) and NPP, providing insight into the P2X7R and NPP, discussing the pathological mechanism of P2 X7R in NPP and the biological characteristics of P2X7R antagonist inhibiting its over-expression for the targeted therapy of NPP. |
| Databáze: | OpenAIRE |
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