Normalized power variance of eLORETA at high-convexity area predicts shunt response in idiopathic normal pressure hydrocephalus

Autor: Hiroaki Kazui, Kyosuke Kakeda, Ricardo Bruña, Yasunori Aoki, Takuya Matsumoto, Hideki Kanemoto, Tamiki Wada, Roberto D. Pascual-Marqui, Masao Iwase, Yukiko Suzuki, Ryouhei Ishii, Takashi Suehiro, Manabu Ikeda, Kenji Yoshiyama, Masahiro Hata, Leonides Canuet
Přispěvatelé: University of Zurich, Aoki, Yasunori
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
lcsh:Medicine
Neurophysiology
Urinary incontinence
610 Medicine & health
Electroencephalography
Article
Shunt operation
03 medical and health sciences
0302 clinical medicine
Cerebrospinal fluid
Cognition
Internal medicine
Medicine
Humans
lcsh:Science
Gait
Aged
1000 Multidisciplinary
Multidisciplinary
medicine.diagnostic_test
business.industry
Gait Disturbance
lcsh:R
medicine.disease
10074 The KEY Institute for Brain-Mind Research
Cerebrospinal Fluid Shunts
Hydrocephalus
Normal Pressure
Hydrocephalus
Electrophysiological Phenomena
030104 developmental biology
10054 Clinic for Psychiatry
Psychotherapy
and Psychosomatics
(Idiopathic) normal pressure hydrocephalus
Cardiology
lcsh:Q
Female
medicine.symptom
business
Psychiatric disorders
030217 neurology & neurosurgery
Shunt (electrical)
Zdroj: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
ISSN: 2045-2322
Popis: Idiopathic normal pressure hydrocephalus (iNPH) is a neuropsychiatric disease characterized by gait disturbance, cognitive deterioration and urinary incontinence associated with excessive accumulation of cerebrospinal fluid (CSF) in the brain ventricles. These symptoms, in particular gait disturbance, can be potentially improved by shunt operation in the early stage of the disease, and the intervention associates with a worse outcome when performed late during the course of the disease. Despite the variable outcome of shunt operation, noninvasive presurgical prediction methods of shunt response have not been established yet. In the present study, we used normalized power variance (NPV), a sensitive measure of the instability of cortical electrical activity, to analyze cortical electrical activity derived from EEG data using exact-low-resolution-electromagnetic-tomography (eLORETA) in 15 shunt responders and 19 non-responders. We found that shunt responders showed significantly higher NPV values at high-convexity areas in beta frequency band than non-responders. In addition, using this difference, we could discriminate shunt responders from non-responders with leave-one-subject-out cross-validation accuracy of 67.6% (23/34) [positive predictive value of 61.1% (11/18) and negative predictive value of 75.0% (12/16)]. Our findings indicate that eLORETA-NPV can be a useful tool for noninvasive prediction of clinical response to shunt operation in patients with iNPH.
Databáze: OpenAIRE
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