Dysplasia and Dysregulation of Proliferation in Foveolar and Surface Epithelia of Fundic Gland Polyps From Patients With Familial Adenomatous Polyposis
| Autor: | John H. Yardley, Stanley R. Hamilton, Asif Rashid, Tsung Teh Wu, Susan Kornacki |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Cyclin-Dependent Kinase Inhibitor p21 Male medicine.medical_specialty Pathology Gastroenterology Epithelium Pathology and Forensic Medicine Familial adenomatous polyposis Polyps Fundic gland polyposis Stomach Neoplasms Cyclins Internal medicine medicine Humans Gastric Fundus neoplasms Aged business.industry Stomach Middle Aged medicine.disease digestive system diseases Foveolar cell Fundic Gland Polyp Ki-67 Antigen medicine.anatomical_structure Adenomatous Polyposis Coli Dysplasia Immunohistochemistry Female Surgery Histopathology Anatomy business Cell Division |
| Zdroj: | The American Journal of Surgical Pathology. 22:293-298 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/00000478-199803000-00003 |
| Popis: | Fundic gland polyps (FGPs) of the stomach are regarded as hamartomatous or hyperplastic/functional polyps that occur sporadically but at increased frequency in patients with familial adenomatous polyposis syndrome (FAP). There is controversy about the histopathology of FGPs, including occurrence of dysplasia. We, therefore, studied dysplasia in 270 sporadic FGPs from 216 patients and 49 FGPs from 24 patients with FAP. We evaluated dysregulation of epithelial proliferation manifested by loss of the normal inverse topographic distribution of Ki-67 proliferation marker and the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) using immunohistochemistry in 27 sporadic FGPs and in 22 FGPs from patients with FAP. Dysplasia in foveolar and surface epithelia occurred in 12 of 49 (25%) FGPs in patients with FAP but in only 3 of 270 (1%) of sporadic FGPs (p < 0.000001). Fourteen of 49 (29%) of FGPs from patients with FAP were indefinite for dysplasia, as contrasted with 8 of 270 (3%) sporadic FGPs (p < 0.00001). The normal inverse topographic distribution of Ki-67 and p21(WAF1/CIP1) was maintained in 20 of 22 (91%) of FGPs negative for dysplasia but was lost in all (8 of 8) FGPs with dysplasia and in 11 of 19 (58%) FGPs that were indefinite for dysplasia (p = 0.00001). The results indicate that dysplasia can occur in foveolar and surface epithelia of FGPs, especially in patients with FAP, and often is preceded by dysregulation of epithelial proliferation when the morphologic abnormalities are indefinite for dysplasia. |
| Databáze: | OpenAIRE |
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