Interleukin 18 as a Marker of Chronic Nephropathy in Children after Anticancer Treatment
| Autor: | Wojciech Młynarski, Małgorzata Zubowska, Beata Zalewska-Szewczyk, Wojciech Fendler, Krystyna Wyka |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Pathology Article Subject Adolescent medicine.medical_treatment Clinical Biochemistry Renal function Antineoplastic Agents Kidney Wilms Tumor Gastroenterology Carboplatin Nephrotoxicity Nephropathy chemistry.chemical_compound Tubulopathy Internal medicine Genetics medicine Humans Ifosfamide Renal Insufficiency Chronic Child Molecular Biology lcsh:R5-920 Beta-2 microglobulin business.industry Biochemistry (medical) Interleukin-18 General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Kidney Neoplasms Nephrectomy medicine.anatomical_structure ROC Curve chemistry Child Preschool Clinical Study Female Cisplatin lcsh:Medicine (General) beta 2-Microglobulin business Biomarkers |
| Zdroj: | Disease Markers Disease Markers, Vol 35, Iss 6, Pp 811-818 (2013) |
| ISSN: | 1875-8630 0278-0240 |
| Popis: | Novel markers of nephrotoxicity, including kidney injury molecule 1 (KIM-1), interleukin 18 (IL-18), and beta-2 microglobulin, were used in the detection of acute renal injury. The aim of the study was to establish the frequency of postchemotherapy chronic kidney dysfunction in children and to assess the efficacy of IL-18, KIM-1, and beta-2 microglobulin in the detection of chronic nephropathy. We examined eighty-five patients after chemotherapy (median age of twelve years). The median age at the point of diagnosis was 4.2 years, and the median follow-up time was 4.6 years. We performed classic laboratory tests assessing kidney function and compared the results with novel markers (KIM-1, beta-2 microglobulin, and IL-18). Features of subclinical renal injury were identified in forty-eight children (56.3% of the examined group). Nephropathy, especially tubulopathy, appeared more frequently in patients treated with ifosfamide, cisplatin, and/or carboplatin, following nephrectomy or abdominal radiotherapy (P=0.14,P=0.11, andP=0.08, resp.). Concentrations of IL-18 and beta-2 microglobulin were comparable with classic signs of tubulopathy (P=0.0001andP=0.05). Concentrations of IL-18 were also significantly higher in children treated with highly nephrotoxic drugs (P=0.0004) following nephrectomy (P=0.0007) and abdominal radiotherapy (P=0.01). Concentrations of beta-2 microglobulin were higher after highly toxic chemotherapy (P=0.004) and after radiotherapy (P=0.02). ROC curves created utilizing IL-18 data allowed us to distinguish between children with nephropathy (value 28.8 pg/mL) and tubulopathy (37.1 pg/mL). Beta-2 microglobulin and IL-18 seem to be promising markers of chronic renal injury in children after chemotherapy. |
| Databáze: | OpenAIRE |
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