Sodium nitroprusside as a nitric oxide donor in a rat intestinal ischemiareperfusion model
| Autor: | Orhan Bayram, Bulent Salman, Ziya Anadol, Okhan Kadir Akin, Ali Ugur Emre, Sevim Ercan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_treatment
Statistical difference Ischemia Pharmacology Nitric oxide chemistry.chemical_compound NG-Nitroarginine Methyl Ester medicine Sodium nitroprusside Saline lcsh:R5-920 business.industry General Medicine medicine.disease Malondialdehyde Intestine Basic Research chemistry Anesthesia Reperfusion Rat lcsh:Medicine (General) business Reperfusion injury medicine.drug |
| Zdroj: | Clinics; v. 63 n. 1 (2008); 91-96 Clinics; Vol. 63 Núm. 1 (2008); 91-96 Clinics; Vol. 63 No. 1 (2008); 91-96 Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Volume: 63, Issue: 1, Pages: 91-96, Published: 2008 Clinics (Sao Paulo, Brazil) Clinics, Vol 63, Iss 1, Pp 91-96 (2008) |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | AIM: The aim of this study was to investigate the efficacy of sodium nitroprusside in the reduction of the intestinal ischemiareperfusion injury as a nitric oxide donor after intraperitoneal administration. METHODS: The histopathological examinations and tissue malonyldialdehyde levels of 35 Wistar albino rats that were subjected to ischemia-reperfusion, were performed in 5 groups. The groups include Control, Ischemia -reperfusion, Sodium nitroprusside, NG-Nitro-L-Arginine Methyl Ester (L-NAME) and Sodium nitroprusside+L-NAME. Each rat was subjected to ischemia for 40 minutes and reperfusion for 30 minutes, except the control group. The medications were done intraperitoneally as saline 4 ml/kg, Sodium nitroprusside 5 mg/kg, L-NAME 10 mg/kg just before reperfusions. RESULTS: Significant tissue injury in histological sections and an increase in tissue levels of Malonyldialdehyde was detected in the I/R group. The efficacy of intraperitoneal administration of Sodium nitroprusside in both Sodium nitroprusside alone and Sodium nitroprusside+L-NAME groups was found statistically significant for the reducing of injury scores (p |
| Databáze: | OpenAIRE |
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