Compound muscle action potential scan and MScanFit motor unit number estimation during Wallerian degeneration after nerve transections

Autor: Nermin Mammadova, Emel Oguz-Akarsu, Elif Kocasoy-Orhan, Mehmet Baris Baslo, Ozlem Kesim-Sahin, Tugrul Artug, Nermin Gorkem Sirin, Ali Emre Oge, Bahar Erbas, Ufuk Emekli
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Wallerian degeneration
Adolescent
Physiology
Neural Conduction
Action Potentials
030105 genetics & heredity
Stimulus (physiology)
Positive correlation
Young Adult
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Peripheral Nerve Injuries
Physiology (medical)
Internal medicine
medicine
Humans
Motor unit number estimation
MScanFit
Ulnar Nerve
MUNE
Motor Neurons
Denervation
CMAP Scan
Stimulus Response Curve
Electromyography
business.industry
Electrodiagnosis
Peripheral Nerve Injury
Middle Aged
medicine.disease
Median Nerve
Compound muscle action potential
medicine.anatomical_structure
Peripheral nerve injury
Disease Progression
Cardiology
Female
Neurology (clinical)
Wallerian Degeneration
business
030217 neurology & neurosurgery
Reinnervation
Zdroj: Muscle & Nerve. 62:239-246
ISSN: 1097-4598
0148-639X
Popis: BACKGROUND Compound muscle action potential (CMAP) scan and MScanFit have been used to understand the consequences of denervation and reinnervation. This study aimed to monitor these parameters during Wallerian degeneration (WD) after acute nerve transections (ANT). METHODS Beginning after urgent surgery, CMAP scans were recorded at 1-2 day intervals in 12 patients with ANT of the ulnar or median nerves, by stimulating the distal stump (DS). Stimulus intensities (SI), steps, returners, and MScanFit were calculated. Studies were grouped according to the examination time after ANT. Results were compared with those of 27 controls. RESULTS CMAP amplitudes and MScanFit progressively declined, revealing a positive correlation with one another. SIs were higher in WD groups than controls. Steps appeared or disappeared in follow-up scans. The late WD group had higher returner% than the early WD and control groups. CONCLUSIONS MScanFit can monitor neuromuscular dysfunction during WD. SIs revealed excitability changes in DS.
Databáze: OpenAIRE
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