Compound muscle action potential scan and MScanFit motor unit number estimation during Wallerian degeneration after nerve transections
Autor: | Nermin Mammadova, Emel Oguz-Akarsu, Elif Kocasoy-Orhan, Mehmet Baris Baslo, Ozlem Kesim-Sahin, Tugrul Artug, Nermin Gorkem Sirin, Ali Emre Oge, Bahar Erbas, Ufuk Emekli |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Wallerian degeneration Adolescent Physiology Neural Conduction Action Potentials 030105 genetics & heredity Stimulus (physiology) Positive correlation Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Peripheral Nerve Injuries Physiology (medical) Internal medicine medicine Humans Motor unit number estimation MScanFit Ulnar Nerve MUNE Motor Neurons Denervation CMAP Scan Stimulus Response Curve Electromyography business.industry Electrodiagnosis Peripheral Nerve Injury Middle Aged medicine.disease Median Nerve Compound muscle action potential medicine.anatomical_structure Peripheral nerve injury Disease Progression Cardiology Female Neurology (clinical) Wallerian Degeneration business 030217 neurology & neurosurgery Reinnervation |
Zdroj: | Muscle & Nerve. 62:239-246 |
ISSN: | 1097-4598 0148-639X |
Popis: | BACKGROUND Compound muscle action potential (CMAP) scan and MScanFit have been used to understand the consequences of denervation and reinnervation. This study aimed to monitor these parameters during Wallerian degeneration (WD) after acute nerve transections (ANT). METHODS Beginning after urgent surgery, CMAP scans were recorded at 1-2 day intervals in 12 patients with ANT of the ulnar or median nerves, by stimulating the distal stump (DS). Stimulus intensities (SI), steps, returners, and MScanFit were calculated. Studies were grouped according to the examination time after ANT. Results were compared with those of 27 controls. RESULTS CMAP amplitudes and MScanFit progressively declined, revealing a positive correlation with one another. SIs were higher in WD groups than controls. Steps appeared or disappeared in follow-up scans. The late WD group had higher returner% than the early WD and control groups. CONCLUSIONS MScanFit can monitor neuromuscular dysfunction during WD. SIs revealed excitability changes in DS. |
Databáze: | OpenAIRE |
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