Associations of Genetic Variations in MicroRNA Seed Regions With Acute Adverse Events and Survival in Patients With Rectal Cancer Receiving Postoperative Chemoradiation Therapy
| Autor: | Weihu Wang, Yanru Feng, Ying Huang, Yexiong Li, Dongxin Lin, Jie Yang, Yan Qiao, Yueping Liu, Ting Feng, Yongwen Song, Wen Tan, Meng Zhang, Hongmin Li, Shulian Wang, Hua Ren, Jing Jin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Diarrhea Male Cancer Research medicine.medical_specialty Antimetabolites Antineoplastic Genotype Colorectal cancer Single-nucleotide polymorphism Dermatitis Kaplan-Meier Estimate Gastroenterology Polymorphism Single Nucleotide Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Statistical significance Internal medicine Medicine Humans Radiology Nuclear Medicine and imaging Adverse effect Capecitabine Postoperative Care Radiation Leukopenia business.industry Rectal Neoplasms Hazard ratio Genetic Variation Odds ratio Chemoradiotherapy Adjuvant Middle Aged medicine.disease Confidence interval MicroRNAs 030104 developmental biology Oncology 030220 oncology & carcinogenesis Female medicine.symptom business |
| Zdroj: | International journal of radiation oncology, biology, physics. 100(4) |
| ISSN: | 1879-355X |
| Popis: | Purpose The aim of this study was to investigate the associations between single nucleotide polymorphisms (SNPs) in the seed regions of microRNAs and acute adverse events (AEs) and survival in patients with rectal cancer receiving postoperative chemoradiation therapy. Methods and Materials Eighteen SNPs were genotyped in 365 patients with rectal cancer receiving postoperative chemoradiation therapy. The associations between genotypes and AEs were estimated by odds ratios and 95% confidence intervals (CIs), which were computed by using multivariate logistic regression models. The hazard ratios and 95% CIs to assess the death of patients for different genotypes were calculated by Cox proportional regression models. Overall survival and disease-free survival of patients with different genotypes were estimated by Kaplan-Meier plots, and the statistical significance was determined by using the log-rank test. Results In these patients, the most common grade ≥2 AEs were diarrhea (44.1%), leukopenia (29.6%), and dermatitis (18.9%). With false discovery rate correction, SNP rs2273626 was significantly associated with a decreased risk of grade ≥2 leukopenia (odds ratio, 0.48; 95% CI, 0.31-0.74; P = .0009). In addition, SNP rs202195689 was associated with overall survival and disease-free survival in patients receiving postoperative chemoradiation therapy, with the hazard ratios for death being 2.02 (95% CI, 1.36-3.01; P = .0006) and 1.91 (95% CI, 1.36-2.70; P = .0002), respectively. However, no significant association between these SNPs and diarrhea and dermatitis was observed. Conclusions These results suggest that rs2273626 and rs202195689 in microRNA seed regions might serve as independent biomarkers for predicting AEs and prognosis in patients with rectal cancer receiving postoperative chemoradiation therapy. Independent replication of these findings is required to confirm these results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|