Recurrence rates and long-term survival factors in young women with breast cancer
| Autor: | Mohammed O. Nassif, Hassan K. Abdulwassi, Abdullah A. Alnajjar, Ahmad H. Alhibshi, Abdulrahman K. Bahatheq, Ibrahim T. Amer, Nora Trabulsi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors recurrence lcsh:Medicine Breast Neoplasms Kaplan-Meier Estimate 030204 cardiovascular system & hematology Systemic therapy survival Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer Internal medicine saudi arabia Medicine Humans 030212 general & internal medicine Stage (cooking) Neoplasm Staging Retrospective Studies young women Chi-Square Distribution business.industry Medical record Hazard ratio lcsh:R Age Factors General Medicine medicine.disease Prognosis Confidence interval Survival Rate Quartile Chemotherapy Adjuvant Original Article Female Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Saudi Medical Journal, Vol 41, Iss 4, Pp 393-399 (2020) Saudi Medical Journal |
| ISSN: | 1658-3175 0379-5284 |
| Popis: | Objectives : To evaluate the factors related to breast cancer (BC) recurrence as well as survival in women ≤40 years old. Methods : Th is is a retrospective medical record review of women aged ≤40 years diagnosed with BC stages I to III between January 2009 and June 2017 at King Abdulaziz University Hospital (KAUH), Jeddah, Saudi Arabia. Demographic data collected included patients’ initial presentation (including age and date of diagnosis), imaging studies, tumor characteristics, type of surgery, systemic therapy (if any) received, and site of first recurrence. Data was analyzed to assess recurrence rate, disease-free survival (DFS), and overall survival (OS), and determine associated factors. Descriptive statistics were used to calculate the mean, median, standard deviation, and quartiles. Chi-square test was performed to test the association between 2 variables. Kaplan-Meier analyses were performed to assess survival distribution. Results : A total of 117 patients were included for analysis. Median follow-up was 16 months (range 0 to 99). Five-year DFS 57% and OS was 89%. Adjuvant chemotherapy was associated with a better DFS (hazard ratio of 0.204; 95% confidence interval, 0.050 to 0.832; p =0.027). Higher tumor, node, metastasis stage was significantly associated with worse DFS ( p =0.034). Fewer postoperative follow-up visits signi cantly predicted recurrence ( p =0.003). Conclusion : We found a high risk of BC recurrence among patients at our institution. Higher cancer stage, nonuse adjuvant chemotherapy, and low follow-up rate were significant predictive factors for recurrence. Saudi Med J 2020; Vol. 41 (4): 393-399 doi: 10.15537/smj.2020.4.24987 How to cite this article: Abdulwassi HK, Amer IT, Alhibshi AH, Alnajjar AA, Bahatheq AK, Trabulsi NH, Nassif MO. Recurrence rates and long-term survival factors in young women with breast cancer. Saudi Med J 2020; Vol. 41 (4): 393-399. doi: 10.15537/smj.2020.4.24987 |
| Databáze: | OpenAIRE |
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