Markers Of Inflammation And Mortality In A Cohort Of Patients With Alcohol Dependence
| Autor: | Fuster, Daniel, Sanvisens, Arantza, Bolao, Ferran, Zuluaga Cruz, Andrea Paola, Rivas, Inmaculada, Tor Aguilera, Jordi, Muga, Roberto, Universitat Autònoma de Barcelona |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Erythrocyte Indices Male medicine.medical_specialty Anemia Ferritin levels Observational Study Inflammation Fibrinogen Gastroenterology Article Cohort Studies Internal medicine medicine Humans Longitudinal Studies Liver Diseases Alcoholic Intestinal permeability business.industry Alcohol dependence General Medicine Alcoholic liver diseases medicine.disease Hepatopaties alcohòliques Surgery Alcoholism Cardiovascular Diseases Alcoholisme Ferritins Cohort Female medicine.symptom business Cohort study medicine.drug |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Medicine |
| Popis: | Altres ajuts: MSSSI/EC11-042 Altres ajuts: MSSSI/PNSD-2014I042 Abstract.Inflammation and intestinal permeability are believed to be paramount features in the development of alcohol-related liver damage. We aimed to assess the impact of 3 surrogate markers of inflammation (anemia, fibrinogen, and ferritin levels) on mid-term mortality of patients with alcohol dependence. This longitudinal study included patients with alcohol dependence admitted for hospital detoxification between 2000 and 2010. Mortality was ascertained from clinical charts and the mortality register. Associations between markers of inflammation and all-cause mortality were analyzed with mortality rates and Cox proportional hazards regression models. We also performed a subgroup analysis of mortality rates in patients with anemia, based on their mean corpuscular volume (MCV). We included 909 consecutive patients with alcohol dependence. Patients were mostly male (80.3%), had a median age of 44 years (interquartile range [IQR]: 38-50), and upon admission, their median alcohol consumption was 192 g/day (IQR: 120-265). At admission, 182 (20.5%) patients had anemia; 210 (25.9%) had fibrinogen levels >4.5 mg/dL; and 365 (49.5%) had ferritin levels >200 ng/mL. At the end of follow-up (median 3.8 years [IQR: 1.8-6.5], and a total of 3861.07 person-years), 118 patients had died (12.9% of the study population). Cox regression models showed that the presence of anemia at baseline was associated with mortality (hazard ratio [HR]: 1.67, 95% confidence interval [CI]: 1.11-2.52, P |
| Databáze: | OpenAIRE |
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