KRAS-mutated Uterine Endometrioid Carcinoma With Extensive Surface Changes Resulting in Striking Morphologic Mimicry of an Ovarian Serous Borderline Tumor
| Autor: | Filiz Ozen, Zeynep Cagla Olgun, Gozde Kir, Humeyra Gunel, W. Glenn McCluggage |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty endocrine system diseases Serous carcinoma Estrogen receptor Serous borderline tumor Hysterectomy medicine.disease_cause Pathology and Forensic Medicine Diagnosis Differential Proto-Oncogene Proteins p21(ras) 03 medical and health sciences 0302 clinical medicine Carcinoma medicine Humans Cervical Microglandular Hyperplasia Neoplasm WT1 Proteins neoplasms Aged Ovarian Neoplasms business.industry Obstetrics and Gynecology medicine.disease Immunohistochemistry female genital diseases and pregnancy complications Cystadenocarcinoma Serous 030104 developmental biology Receptors Estrogen 030220 oncology & carcinogenesis Mutation Uterine Neoplasms Female KRAS Tumor Suppressor Protein p53 business Carcinoma Endometrioid Kras mutation |
| Zdroj: | International Journal of Gynecological Pathology. 39:573-577 |
| ISSN: | 0277-1691 |
| Popis: | Surface epithelial changes involving endometrioid carcinomas of the uterine corpus mimicking papillary syncytial metaplasia or cervical microglandular hyperplasia are relatively common. There have been rare reports of surface epithelial changes in endometrioid carcinomas mimicking ovarian serous borderline tumor or low-grade serous carcinoma. We report an endometrioid carcinoma of the uterine corpus with striking morphologic mimicking of an ovarian serous borderline tumor with only a minimal amount of conventional endometrioid carcinoma. The tumor was diffusely positive for estrogen receptor, negative for WT1, and showed wild-type immunoreactivity with p53. Targeted sequencing revealed a KRAS mutation (G12V/D/A), but no BRAF mutation. This close mimicry of a serous borderline tumor by a uterine endometrioid carcinoma has not been emphasized in the literature and this case is unique because the features involved almost the entire neoplasm. In reporting this case, we review surface changes in endometrioid carcinomas of the uterine corpus. |
| Databáze: | OpenAIRE |
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