Localization of the LDHA gene to 11p14----11p15 by in situ hybridization of an LDHA cDNA probe to two translocations with breakpoints in 11p13
| Autor: | G. A. P. Bruns, Uta Francke, Teresa L. Yang-Feng, K. Simola, Andrew J. Carroll |
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| Rok vydání: | 1986 |
| Předmět: |
Chromosomal translocation
In situ hybridization Biology Translocation Genetic Cell Line 03 medical and health sciences Nucleic acid thermodynamics Complementary DNA Genetics Humans Gene Genetics (clinical) 030304 developmental biology 0303 health sciences L-Lactate Dehydrogenase Chromosomes Human Pair 11 030305 genetics & heredity Breakpoint Chromosome Chromosome Mapping Nucleic Acid Hybridization Karyotype DNA Molecular biology Chromosome Banding Isoenzymes Karyotyping |
| Zdroj: | Human genetics. 74(4) |
| ISSN: | 0340-6717 |
| Popis: | Lymphoblastoid cell lines established from two individuals with apparently balanced translocations involving 11p13 were used for LDHA regional localization. The karyotypes were 46,XY,t(4;11)(q21;p13) and 46,XY,t(1;11)(p22;p13). In situ hybridization of a human LDHA cDNA probe to chromosome preparations from these cell lines resulted in specific labeling over bands p14----p15 of the normal chromosomes 11 and over bands 11p14----11p15 of the derivative chromosomes 4 and 1. These results exclude LDHA from any region proximal to 11p13 and localize the gene to 11p14----11p15. |
| Databáze: | OpenAIRE |
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