The antioxidative property of melatonin against brain ischemia
| Autor: | Emanuela Esposito, Irene Paterniti, Salvatore Cuzzocrea, Marika Cordaro |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Antioxidant Free Radicals Kynuramine medicine.medical_treatment Cell Ischemia-reperfusion injury Biology Pharmacology medicine.disease_cause Antioxidants Brain Ischemia Brain ischemia Melatonin 03 medical and health sciences Antioxidant Free radicals Ischemia-reperfusion injury Melatonin Oxidative stress Neurology (clinical) Neuroscience (all) Pharmacology (medical) 0302 clinical medicine Tissue damage medicine Humans Pharmacology (medical) chemistry.chemical_classification Neuroscience (all) General Neuroscience medicine.disease 030104 developmental biology Enzyme medicine.anatomical_structure chemistry Biochemistry Oxidative stress Neurology (clinical) 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Expert Review of Neurotherapeutics. 16:841-848 |
| ISSN: | 1744-8360 1473-7175 |
| DOI: | 10.1080/14737175.2016.1182020 |
| Popis: | Introduction: This review briefly summarizes some of the large amount of data documenting the ability of melatonin to limit molecular and organ tissue damage in neural ischemia-reperfusion injury (stroke), where free radicals are generally considered as being responsible for much of the resulting tissue destruction.Area Covered: Melatonin actions that have been identified include its ability to directly neutralize a number of toxic reactants and stimulate antioxidative enzymes. Furthermore, several of its metabolites such as N1-acetyl-N2-formyl-5- methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMF), are themselves scavengers suggesting that there is a cascade of reactions that greatly increase the efficacy of melatonin.Expert Commentary: However, the mechanisms by which melatonin is protective in such widely diverse areas of the cell and different organs are likely not yet all identified. |
| Databáze: | OpenAIRE |
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