Inhibiting scrapie neuroinvasion by polyene antibiotic treatment of SCID mice
| Autor: | Jean-Philippe Deslys, Karim Tarik Adjou, Michel Seman, R Demaimay, F. Lamoury, Dominique Dormont, C I Lasmézas, Vincent Beringue |
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| Rok vydání: | 1999 |
| Předmět: |
Drug
Prions medicine.drug_class media_common.quotation_subject Antibiotics Scrapie Mice SCID Scid mice Biology Antiviral Agents Nervous System Mice chemistry.chemical_compound Peripheral nerve Amphotericin B Virology medicine Animals media_common Polyene Mechanism of action chemistry Immunology medicine.symptom Infectious agent |
| Zdroj: | Journal of General Virology. 80:1873-1877 |
| ISSN: | 1465-2099 0022-1317 |
| Popis: | The polyene antibiotic MS-8209 is currently one of the most effective drugs in the treatment of experimental scrapie. However, its mechanism of action and its site of intervention in the pathogenetical process of scrapie infection are largely unknown. It has been shown previously that the infection of immunodeficient SCID mice by the peripheral route provides a reliable model for direct scrapie neuroinvasion, bypassing the lymphoreticular system. Indeed, a proportion of SCID mice develop scrapie after a similar time to immunocompetent mice, despite their severe immune impairment. This model is now used to clarify the targets of MS-8209. In SCID mice, MS-8209 treatment protected against infection but did not prolong survival time. In SCID mice immunologically reconstituted prior to inoculation, the drug delayed the disease without an effect on the attack rate. These findings strongly suggest that MS-8209 acts by hampering the first step of the neuroinvasion process, i.e. the uptake of the infectious agent by peripheral nerve endings. The mechanism leading to the inhibition of agent propagation to nervous cells is discussed with regard to the properties of polyene antibiotics. |
| Databáze: | OpenAIRE |
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