Case-Control Study of Posttreatment Regression of Urinary Tract Morbidity Among Adults in Schistosoma haematobium-Endemic Communities in Kwale County, Kenya
| Autor: | Edmund Ireri, Eric M. Muchiri, Hilda Kadzo, Philip Magak, Charles H. King, Uriel Kitron, Alicia Chang-Cojulun |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Urinary system Population Disease Praziquantel Schistosomiasis haematobia Young Adult Virology Internal medicine parasitic diseases medicine Prevalence Animals Humans Young adult education Urinary Tract Obstructive uropathy Aged Schistosoma haematobium Aged 80 and over education.field_of_study biology business.industry Case-control study Articles Middle Aged biology.organism_classification medicine.disease Kenya Surgery Infectious Diseases Case-Control Studies Parasitology Female Morbidity business medicine.drug Follow-Up Studies |
| Zdroj: | The American journal of tropical medicine and hygiene. 93(2) |
| ISSN: | 1476-1645 |
| Popis: | Previous population-based studies have examined treatment impact on Schistosoma-associated urinary tract disease among children, but much less is known about longer-term treatment benefits for affected adult populations in areas where risk of recurrent infection is high. In communities in Msambweni, along the Kenya coast, we identified, using a portable ultrasound, 77 adults (aged 17-85) with moderate-to-severe obstructive uropathy or bladder disease due to Schistosoma haematobium. Treatment response was assessed by repeat ultrasound 1-2 years after praziquantel (PZQ) therapy and compared with interval changes among age- and sex-matched infected/treated control subjects who did not have urinary tract abnormalities at the time of initial examination. Of the 77 affected adults, 62 (81%) had improvement in bladder and/or kidney scores after treatment, 14 (18%) had no change, and one (1.3%) had progression of disease. Of the 77 controls, 75 (97%) remained disease free by ultrasound, while two (3%) had apparent progression with abnormal findings on follow-up examination. We conclude that PZQ therapy for S. haematobium is effective in significantly reducing urinary tract morbidity from urogenital schistosomiasis among adult age groups, and affected adults stand to benefit from inclusion in mass treatment campaigns. |
| Databáze: | OpenAIRE |
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