MicroRNA155 Expression in Relation to BDCAF Scored Behçet's Disease in an Egyptian Patients' Sample
Autor: | Eman H. Elsayed, Sally S. Hassouna, Ahmed M. Abdelhady, Manal Y. Tayel, Dalal El-Kaffash |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
MicroRNA155 medicine.medical_specialty Behçet's disease business.industry Egyptian patients miRNA155 Healthy subjects Disease Behcet's disease medicine.disease BDCAF Gastroenterology Disease activity 03 medical and health sciences 030104 developmental biology Rheumatology Internal medicine CD40 Medicine Biomarker (medicine) business |
Zdroj: | The Open Rheumatology Journal |
ISSN: | 1874-3129 |
Popis: | Objective:To discover the possibility of using microRNA155 (miRNA155) expression level as a biomarker of Behçet's Disease (BD) activity or remission.Methods:Thirty BD patients’ white blood cells (WBCs) miRNA155 expression was measured and compared to WBCs miRNA155 expression in 15 healthy subjects. Assessment of disease activity was done using Behçet's Disease Current Activity Form (BDCAF).Results:miRNA155 expression significantly decreases with the increase of BD activity scored by BDCAF.Conclusion:Increased miRNA155 may be used as a biomarker of BD remission and thus in the disease follow up. There could be a prospect of treating the diseaseviamicroRNA 155 effect enhancement. |
Databáze: | OpenAIRE |
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