Can breast MRI and adjunctive Doppler ultrasound improve the accuracy of predicting pathological complete response after neoadjuvant chemotherapy?
| Autor: | Takashi Sugino, Takayoshi Uematsu, Tomomi Hayashi, Yukiko Tadokoro, Akifumi Notsu, Junichiro Watanabe, Kazuaki Nakashima, Seiichirou Nishimura, Taiyo L Harada, Kaoru Takahashi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Neoplasm Residual medicine.medical_treatment Breast Neoplasms 03 medical and health sciences symbols.namesake 0302 clinical medicine Breast cancer Surgical oncology medicine Breast MRI Humans Pharmacology (medical) Radiology Nuclear Medicine and imaging Pathological Neoadjuvant therapy Aged Retrospective Studies Aged 80 and over Chemotherapy medicine.diagnostic_test business.industry Magnetic resonance imaging Ultrasonography Doppler General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Neoadjuvant Therapy 030104 developmental biology Oncology 030220 oncology & carcinogenesis symbols Female Radiology business Doppler effect |
| Zdroj: | Breast cancer (Tokyo, Japan). 28(5) |
| ISSN: | 1880-4233 |
| Popis: | To examine the accuracy of MRI and Doppler ultrasound (US) for detecting residual tumor after neoadjuvant chemotherapy (NAC) for breast cancer and evaluate whether adjunctive Doppler US improves the MRI accuracy. We reviewed 276 invasive breast cancer cases treated with NAC. Tumors were classified into four subtypes based on estrogen receptor and HER2 status. Response to NAC was evaluated using contrast-enhanced MRI and Doppler US. Residual Doppler flow was assumed to indicate a residual tumor. MRI and Doppler findings were compared with the histopathological findings of resected specimens. Pathological complete response (pCR) was defined as neither in situ nor invasive cancer left. Of the 276 tumors, imaging complete responses were observed using MRI and Doppler US in 62 (22%) and 111 (40%), respectively, whereas pCR was achieved in 44 (16%). MRI and Doppler US predicted residual tumor with 88% and 69% sensitivity, 80% and 91% specificity, 87% and 73% accuracy, 96% and 98% PPV, and 56% and 36% NPV, respectively. The accuracies of MRI and Doppler US were significantly higher for HER2-negative than HER2-positive tumors (p |
| Databáze: | OpenAIRE |
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