On-Line Chemical Composition Analysis of Refillable Electronic Cigarette Aerosol—Measurement of Nicotine and Nicotyrine
Autor: | Brent J. Williams, Walton Sumner, Raul E. Martinez, Steven Dhawan |
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Rok vydání: | 2014 |
Předmět: |
Aerosols
Glycerol Smoke Nicotine Chromatography Gas Chromatography Pyridines Chemistry Public Health Environmental and Occupational Health Absorption (skin) Electronic Nicotine Delivery Systems Propylene Glycol law.invention Aerosol Nicotine metabolism law medicine Humans Chemical composition Electronic cigarette Aerosolization medicine.drug |
Zdroj: | Nicotine & Tobacco Research. 17:1263-1269 |
ISSN: | 1469-994X 1462-2203 |
DOI: | 10.1093/ntr/ntu334 |
Popis: | Introduction Electronic cigarettes (e-cigs) generate aerosols that users inhale. Analyses of e-liquids inconsistently report nicotyrine, a nicotine analog that could impede nicotine metabolism, raising questions about nicotyrine formation. Methods E-cig aerosols were analyzed on-line using a Thermal Desorption Aerosol Gas Chromatograph. Three e-liquids were tested: an unflavored solution in propylene glycol (PG); an unflavored solution in PG and vegetable glycerin (VG), and a flavored solution in PG and VG. A heating duration experiment determined the nicotyrine to nicotine ratio (NNR) in particle phase as a function of the duration of e-cig activation. An aging experiment determined the NNR in e-liquids and aerosols as a function of time since initial exposure to air and storage condition. Results Nicotine and nicotyrine were quantified in all 3 e-liquids and aerosols. Duration of e-cig activation was inversely related to NNR (NNR = 0.04 with 3-s activation, 0.26 with 0.5 s). Aging influenced both e-liquid NNR and aerosol NNR. On average, the e-liquid NNR increased from 0.03 at 11 days after opening to 0.08 after 60 days. For similar heating durations, aerosol NNR increased from 0.05 at 11 days to 0.23 after 60 days. Storage conditions had little effect on NNR. Conclusions E-cig aerosols have variable nicotyrine quantities. Aerosol NNR depends on vaping technique and time elapsed since the e-liquid was exposed to air. It is hypothesized that aerosolized nicotyrine could facilitate nicotine absorption, inhibit the metabolism of nicotine, and reduce a user's urge to smoke. |
Databáze: | OpenAIRE |
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