Hyperuricemia is associated with impaired intestinal permeability in mice
| Autor: | Peng Zhao, Pengjun Wang, Xuena Cui, Xiu Liu, Guangtao Wang, Wan Yang, Daxing Xu, Guanpin Yang, Zenglan Wang, Shichao Xing, Xiaofeng Wang, Xiaomin Yang, Qiulan Lv, Zhiyuan Li |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Lipopolysaccharides medicine.medical_specialty Physiology Hyperuricemia Gut flora Permeability 03 medical and health sciences Mice 0302 clinical medicine Physiology (medical) Internal medicine medicine Animals Mice Knockout Intestinal permeability Hepatology biology business.industry Mechanism (biology) Tumor Necrosis Factor-alpha Gastroenterology medicine.disease biology.organism_classification Lipid Metabolism Immunity Innate Gastrointestinal Microbiome Mice Inbred C57BL 030104 developmental biology Endocrinology Intestinal Absorption 030220 oncology & carcinogenesis Dysbiosis Metabolic syndrome business |
| Zdroj: | American journal of physiology. Gastrointestinal and liver physiology. 317(4) |
| ISSN: | 1522-1547 |
| Popis: | Hyperuricemia is associated with many metabolic diseases. However, the underlying mechanism remains unknown. The gut microbiota has been demonstrated to play significant roles in the immunity and metabolism of the host. In the present study, we constructed a hyperuricemic mouse model to investigate whether the metabolic disorder caused by hyperuricemia is related to intestinal dysbiosis. A significantly increased intestinal permeability was detected in hyperuricemic mice. The difference in microflora between wild-type and hyperuricemic mice accompanies the translocation of gut microbiota to the extraintestinal tissues. Such a process is followed by an increase in innate immune system activation. We observed increased LPS and TNF-α levels in the hyperuricemic mice, indicating that hyperuricemic mice were in a state of low-grade systemic inflammation. In addition, hyperuricemic mice presented early injury of parenteral tissue and disordered lipid metabolism. These findings suggest that intestinal dysbiosis due to an impaired intestinal barrier may be the key cause of metabolic disorders in hyperuricemic mice. Our findings should aid in paving a new way of preventing and treating hyperuricemia and its complications. NEW & NOTEWORTHY Hyperuricemia is associated with many metabolic diseases. However, the underlying mechanism remains unknown. We constructed a hyperuricemic mouse model to explore the relationship between intestinal dysbiosis and metabolic disorder caused by hyperuricemia. |
| Databáze: | OpenAIRE |
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