Effects of GPR81 silencing combined with cisplatin stimulation on biological function in hypopharyngeal squamous cell carcinoma

Autor:	Jinhui Dong, Ou Xu, Xiaofang Jia, Qiaojing Jia, Chunguang Shan, Jianxing Wang, Xiumin Ren
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine Cancer Research Cell Survival Phosphofructokinase-1 Cell cisplatin Receptors Cell Surface Biochemistry Oxidative Phosphorylation Receptors G-Protein-Coupled 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Cell Line Tumor Mitochondrial Precursor Protein Import Complex Proteins Genetics medicine Gene silencing Humans G protein-couple receptor 81 Molecular Biology biological function Cell Proliferation Cisplatin Gene knockdown hypopharyngeal squamous cell carcinoma Hypopharyngeal Neoplasms Oncogene Chemistry Squamous Cell Carcinoma of Head and Neck Membrane Transport Proteins Articles Cell cycle Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure Oncology Apoptosis 030220 oncology & carcinogenesis Gene Knockdown Techniques silencing Cancer research Molecular Medicine Glycolysis medicine.drug
Zdroj:	Molecular Medicine Reports
ISSN:	1791-3004 1791-2997
Popis:	Hypopharyngeal squamous cell carcinoma (HSCC) is a malignant tumor found in the head and neck region. Lactate receptor 1, also known as G protein‑coupled receptor81 (GPR81), has been reported to play a vital role in cancer growth and metabolism. However, the function of GPR81 in HSCC remains largely unknown. The present study investigated the effect of GPR81 on cell survival and GPR81‑mediated energy metabolism under cisplatin treatment in HSCC. GPR81 knockdown reduced the proliferation and invasion of the human HSCC cell line FaDu. Furthermore, GPR81 silencing combined with cisplatin treatment increased the expression of translocase of outer mitochondrial membrane 20 at the mRNA and protein levels (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3823e0e74d4ce714810c3273e9eb6d http://europepmc.org/articles/PMC7411294 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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