Neonatal Airway Immune Profiles and Asthma and Allergy Endpoints in Childhood
| Autor: | Susanne Brix, Jakob Stokholm, Christian J. Carlsson, Klaus Bønnelykke, Helene M. Wolsk, Morten Arendt Rasmussen, Hans Bisgaard, Bo L. Chawes, Ann-Marie Malby Schoos, Nilofar V. Følsgaard |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Allergy Chemokine Respiratory System Immunology Immunoglobulin E Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Pregnancy medicine Humans Immunology and Allergy Mucosal lining fluid Child Children Skin Tests Asthma biology business.industry Infant Newborn Cohort Allergens medicine.disease Rhinitis Allergic respiratory tract diseases 030104 developmental biology 030228 respiratory system biology.protein Cytokines Female CCL26 Chemokines business Airway |
| Zdroj: | Chawes, B L, MygindWolsk, H, Jakob Carlsson, C, Rasmussen, M A, Følsgaard, N, Stokholm, J, Bønnelykke, K, Pedersen, S B, MalbySchoos, A-M & Bisgaard, H F 2021, ' Neonatal Airway Immune Profiles and Asthma and Allergy Endpoints in Childhood ', Allergy, vol. 76, no. 12, pp. 3713-3722 . https://doi.org/10.1111/all.14862 Chawes, B L, Wolsk, H M, Carlsson, C J, Rasmussen, M A, Følsgaard, N, Stokholm, J, Bønnelykke, K, Brix, S, Schoos, A-M M & Bisgaard, H 2021, ' Neonatal airway immune profiles and asthma and allergy endpoints in childhood ', Allergy: European Journal of Allergy and Clinical Immunology, vol. 76, no. 12, pp. 3713-3722 . https://doi.org/10.1111/all.14862 |
| DOI: | 10.1111/all.14862 |
| Popis: | Background: The immune system plays a key role in the pathogenesis of asthma and allergy, but the role of the airway cytokine and chemokine composition in vivo in early life prior to symptom development has not been described previously. Here, we aimed to examine whether the neonatal airway immune composition associates with development of allergy and asthma in childhood. Methods: We measured unstimulated levels of 20 immune mediators related to the Type 1, Type 2, Type 17, or regulatory immune pathways in the airway mucosal lining fluid of 620 one-month-old healthy neonates from the COPSAC2010 birth cohort. Allergy and asthma were diagnosed at our research clinic by predefined algorithms and objective assessments at age 6 years. Principal component analyses were used to describe the airway cytokine and chemokine composition. Results: A neonatal airway immune profile particularly characterized by enhanced IL-1β and reduced CCL26 was significantly associated with later development of elevated specific IgE to inhaled allergens, a positive skin prick test, and allergic rhinitis, but not with food sensitization. Conversely, reduced Type 17 immune-associated markers, including IL-1β and CXCL8, showed trend of association with development of early asthma endpoints. Conclusions: Development of early asthma endpoints and inhalant allergy during the first 6 years of life seems associated with distinctly perturbed airway immune profiles in neonatal life, which is suggestive of an early origin and different pathogenesis of childhood asthma and allergy. These exploratory findings suggest pre- and perinatal life as an important window of opportunity for prevention of asthma and inhalant allergy. |
| Databáze: | OpenAIRE |
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