The effects of long-duration, low-temperature ground transportation on physiological and biochemical indicators of stress in mice
| Autor: | Jung Sik Cho, Yong Kyu Kim, Seung Wan Jee, Chang Joon Bae, Kab Ryong Chae, Sun Bo Shim, Ji Soon Sin, Mee Kyung Jang, Byoung Guk Kim, Chuel Kyu Kim, Dae Youn Hwang, Se Hyun Lee, Byoung Chun Lee, Su Hae Lee |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Serum corticosterone
medicine.medical_specialty Time Factors Transportation Environment Biology Mice Liver disease Internal medicine medicine Animals HSP70 Heat-Shock Proteins Animal Husbandry Endoplasmic Reticulum Chaperone BiP Short duration Heat-Shock Proteins chemistry.chemical_classification Mice Inbred ICR Behavior Animal General Veterinary Ground transportation medicine.disease Enzymes Hsp70 Cold Temperature Mice Inbred C57BL Endocrinology Enzyme chemistry Immunology Animal Science and Zoology Corticosterone Stress Psychological Molecular Chaperones |
| Zdroj: | Lab Animal. 37:121-126 |
| ISSN: | 1548-4475 0093-7355 |
| Popis: | Transportation can cause stress to laboratory animals and alter physiological characteristics that may confound experimental results. The authors investigated stress-related effects of 3-4 h of transportation by truck in two strains of mice (C57BL/6, which are known to be aggressive, and ICR, which are less aggressive). Transported mice had sufficient space and access to water, though temperature in the truck was lower than what is usually recommended. Transportation affected the following parameters in both strains of mice: (i) serum corticosterone concentrations, (ii) expression of the chaperone proteins Hsp70 and Grp78 in various tissues and (iii) concentrations of serological enzymes that are associated with liver disease. These parameters also differed substantially between the two strains of mice. |
| Databáze: | OpenAIRE |
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