When right differs from left : human limb directional asymmetry emerges during very early development

Autor: Sofie Delen, Stefan Van Dongen, Liliane C. D. Wijnaendts, Clara M. A. ten Broek, Kristiina Heikinheimo, Frietson Galis, Jessica Bots
Přispěvatelé: Pathology, Other Research
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Laterality : asymmetries of body, brain and cognition
Laterality, 19(5), 591-601. Taylor and Francis Ltd.
Van Dongen, S, Galis, F, Ten Broek, C, Heikinheimo, K, Wijnaendts, L C D, Delen, S & Bots, J 2014, ' When right differs from left: Human limb directional asymmetry emerges during very early development ', Laterality, vol. 19, no. 5, pp. 591-601 . https://doi.org/10.1080/1357650X.2014.891606
ISSN: 1357-650X
DOI: 10.1080/1357650X.2014.891606
Popis: The often observed directional asymmetry (DA) in human limb bones may have a genetic/developmental basis and/or could emerge from different mechanical loadings across sides due to handedness. Because behavioural lateralization in itself has a genetic basis, it has been suggested that DA in limbs could develop prenatally as a pre-adaptation to adult life. However, the presence of consistent differences in the size of left and right limb bones in early development is understudied. We study asymmetry in limb bones during early development (10-20 weeks of gestation) in a sample of 178 aborted foetuses. Statistically significant DA was found in several upper and lower limb bones, where the right-hand side was consistently larger than the left. We argue that this pattern is probably the consequence of developmental processes related to internal asymmetric positioning of organs.
Databáze: OpenAIRE