Fine needle aspiration (FNA) of synovial sarcoma-a comparative histological-cytological study of 15 cases, including immunohistochemical, electron microscopic and cytogenetic examination and DNA-ploidy analysis
| Autor: | Fredrik Mertens, N. Mandahl, Birgitta Carlén, Måns Åkerman, Helena Willén |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Histology Immunocytochemistry Soft Tissue Neoplasms Pathology and Forensic Medicine Diagnosis Differential Sarcoma Synovial Cytology medicine Humans Fibrosarcoma Aged medicine.diagnostic_test business.industry Biopsy Needle DNA Neoplasm General Medicine Middle Aged Flow Cytometry medicine.disease Diploidy Immunohistochemistry Synovial sarcoma Fine-needle aspiration Female Histopathology Spindle cell sarcoma business |
| Zdroj: | Cytopathology. 7:187-200 |
| ISSN: | 0956-5507 |
| Popis: | A retrospective study of 25 FNAs (11 aspirates from primary tumours and 14 from recurrencies and metastases) from 15 synovial sarcomas was performed. The cytological findings were correlated with the histopathology and the value of immunohistochemical and electron microscopic examination as well as DNA-ploidy and cytogenetic analysis for diagnosis were assessed. A reproducible cellular pattern with a reliable diagnosis of spindle cell sarcoma was possible provided that the aspirates were cell rich. However, a true biphasic pattern indicative of synovial sarcoma was only seen in one of the 25 specimens. Electron microscopic examination of the aspirates was a valuable adjunctive diagnostic method, whereas immunocytochemistry and DNA-ploidy analysis were not. Immunohistochemical, electron microscopic and cytogenetic analysis were all valuable ancillary methods when performed on surgical specimens. Malignant haemangiopericytoma and fibrosarcoma were the most important differential diagnoses in the FNA specimens. |
| Databáze: | OpenAIRE |
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