Interstitial pneumonitis possibly due to mitoxantrone
| Autor: | Yoshihiro Matsukawa, Jin Takeuchi, Takashi Horie, Masumi Aiso, Yoku Kitami, Ohshima T, Takashi Hayama, Teruhisa Hagiwara |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Pathology medicine.medical_specialty medicine.medical_treatment Leukemia Myeloid Accelerated Phase medicine Humans Mitoxantrone Chemotherapy medicine.diagnostic_test business.industry Respiratory disease Hematology General Medicine medicine.disease Bronchoalveolar lavage Heart failure Prednisolone Crackles Female medicine.symptom business Lung Diseases Interstitial Infiltration (medical) medicine.drug |
| Zdroj: | Acta haematologica. 90(3) |
| ISSN: | 0001-5792 |
| Popis: | A 41-year-old patient with chronic myelogenous leukemia in the accelerated phase was treated with mitoxantrone. She developed pyrexia 7 days after receiving the third administration of mitoxantrone. After 3 more days, she experienced dry cough and dyspnea. Bilateral fine crackles were audible, but no signs of heart failure were found. A chest X-ray film revealed diffuse reticulogranular infiltrates bilaterally. An increase in the prednisolone dosage led to an improvement. Specimens of the bronchoalveolar lavage revealed an increase in CD4–/CD8– lymphocytes. The peripheral lymphocytes also expressed neither CD4 nor CD8. Specimens of a transbronchial lung biopsy disclosed thickening of the alveolar wall with infiltration of lymphoid cells. |
| Databáze: | OpenAIRE |
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