Commitment and Developmental Potential of Extrathymic and Intrathymic T Cell Precursors: Plenty to Choose from
| Autor: | Juan Carlos Zúñiga-Pflücker, Avinash Bhandoola, Harald von Boehmer, Howard T. Petrie |
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| Rok vydání: | 2007 |
| Předmět: |
B-Lymphocytes
Lineage (genetic) T-Lymphocytes T cell Immunology Thymus Gland Biology Hematopoietic Stem Cells Cell biology Transplantation Haematopoiesis Infectious Diseases medicine.anatomical_structure Bone Marrow medicine Animals Humans Immunology and Allergy Cell Lineage Bone marrow Stem cell Progenitor cell Function (biology) Bone Marrow Transplantation |
| Zdroj: | Immunity. 26:678-689 |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/j.immuni.2007.05.009 |
| Popis: | T cells developing in the thymus are derived from hematopoietic stem cells (HSCs) in the bone marrow (BM). Understanding the developmental steps linking multipotent HSCs to intrathymic T lineage-committed progenitors is important for understanding cancer in T lineage cells, improving T cell reconstitution after BM transplantation, and designing gene-therapy approaches to treat defective T cell development or function. Such an understanding may also help ameliorate immunological defects in aging. This review covers the differentiation steps between HSCs and committed T cell progenitors within the thymus. |
| Databáze: | OpenAIRE |
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