Dietary interventions, intestinal microenvironment, and obesity: a systematic review
| Autor: | Valesca Dall'Alba, Johnny Galhano dos Santos, Bruna Cherubini Alves, Thais Ortiz Hammes |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
030109 nutrition & dietetics Nutrition and Dietetics Diet therapy business.industry Insulin medicine.medical_treatment Psychological intervention Medicine (miscellaneous) Context (language use) Bioinformatics medicine.disease Obesity Clinical trial 03 medical and health sciences 030104 developmental biology medicine Microbiome business Body mass index |
| Zdroj: | Nutrition reviews. |
| ISSN: | 1753-4887 |
| Popis: | Context Obesity has been linked to the intestinal microenvironment. Diet plays an important role in obesity and has been associated with microbiota. Objective This systematic review sought to evaluate the scientific evidence on the effect of dietary modification, including supplementation with prebiotics and probiotics, on microbiota diversity in obesity. Data sources A systematic search was performed in the MEDLINE and EMBASE databases. Studies were considered eligible if they were clinical trials evaluating dietary intervention and microbiota, body weight, or clinical parameters in obesity. Data extraction Data were extracted by 2 independent reviewers. Results From 168 articles identified, 20 were included (n = 931 participants). Increased phyla abundance after food interventions was the main finding in relation to microbiota. Regarding the impact of interventions, increased insulin sensitivity, reduced levels of inflammatory markers, and reduced body mass index were shown in several studies. Conclusions Interventions that modulate microbiota, especially prebiotics, show encouraging results in treating obesity, improving insulin levels, inflammatory markers, and body mass index. Because the studies included in this review were heterogeneous, it is difficult to achieve conclusive and definitive results. |
| Databáze: | OpenAIRE |
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