Pharmacokinetic/Pharmacodynamic Modeling of Spiramycin against Mycoplasma synoviae in Chickens
Autor: | Yousreya H. Hashem, Nayera M. Al-Atfeehy, Seung-Chun Park, Walter H. Hsu, Sara T. Elazab, Eon-Bee Lee, Nahla S. Elshater |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Microbiology (medical)
Withdrawal time Mycoplasma synoviae Pharmacology Minimum inhibitory concentration Pharmacokinetics spiramycin HPLC pharmacokinetics withdrawal time pharmacodynamics medicine Immunology and Allergy Molecular Biology General Immunology and Microbiology business.industry Spiramycin Parallel study biochemical phenomena metabolism and nutrition Bioavailability Infectious Diseases Pharmacodynamics Medicine business medicine.drug |
Zdroj: | Pathogens, Vol 10, Iss 1238, p 1238 (2021) Pathogens; Volume 10; Issue 10; Pages: 1238 |
ISSN: | 2076-0817 |
Popis: | This research aimed to assess the pharmacokinetics/pharmacodynamics (PK/PD) and tissue residues of spiramycin in chickens. The PK of spiramycin were determined in 12 chickens using a parallel study design in which each group of chickens (n = 6) received a single dose of spiramycin at 17 mg/kg intravenously (IV) or orally. Plasma samples were collected at assigned times for up to 48 h to measure spiramycin concentrations. Additionally, a tissue depletion study was performed in 42 chickens receiving spiramycin at 17 mg/kg/day orally for 7 days. The area under the plasma concentration–time curve values were 29.94 ± 4.74 and 23.11 ± 1.83 µg*h/mL after IV and oral administrations, respectively. The oral bioavailability was 77.18%. The computed withdrawal periods of spiramycin were 11, 10, and 7 days for liver, muscle, and skin and fat, respectively. The minimum inhibitory concentration for spiramycin against Mycoplasma synoviae (M. synoviae) strain 1853 was 0.0625 µg/mL. Using the PK/PD integration, the appropriate oral dose of spiramycin against M. synoviae was estimated to be 15.6 mg/kg. Thus, we recommend an oral dose of 15.6 mg spiramycin/kg against M. synoviae in chickens and a withdrawal period of 11 days following oral treatment with 17 mg spiramycin/kg/day for 7 days. |
Databáze: | OpenAIRE |
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