Inhibition of human red blood cell glutathione reductase by valproic acid
| Autor: | Eliezer Lahat, Dita Cotariu, Sandra Evans, Jack Theitler, Jacob L. Zaidman, Tsvy Bistritzer |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Erythrocytes Adolescent medicine.medical_treatment Glutathione reductase Pharmacology Biochemistry chemistry.chemical_compound In vivo medicine Humans Child chemistry.chemical_classification Valproic Acid Dose-Response Relationship Drug Chemistry Glutathione Red blood cell Glutathione Reductase medicine.anatomical_structure Anticonvulsant Enzyme Child Preschool Toxicity lipids (amino acids peptides and proteins) NADP medicine.drug |
| Zdroj: | Biochemical Pharmacology. 43:425-429 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(92)90559-2 |
| Popis: | Glutathione reductase (GR) one of the enzymes of the glutathione redox cycle, plays a salient role in maintaining appropriate cellular levels of reduced glutathione. The enzyme in human red blood cells is inhibited in vitro by the anticonvulsant drug valproic acid (VPA). The inhibition is dose-dependent, reversible, uncompetitive and does not depend on the redox state of the enzyme. VPA also inhibits red blood cell GR activity in children being treated with the drug. The level of serum VPA correlates significantly with the suppression of GR activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|