Inflammatory mediators in saliva and gingival fluid of children with congenital heart defect
| Autor: | Hiba Mohamed Ali, Raouf Whahab Ali, Osama Hafiz Elshazali, Salwa Suliman, Ellen Berggreen, Manal Mustafa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Heart Defects
Congenital Saliva medicine.medical_specialty Necrosis Dental Plaque Heart defect Gastroenterology Crevicular fluid 03 medical and health sciences Gingivitis 0302 clinical medicine Internal medicine Medicine Humans Prostaglandin E2 Child General Dentistry Inflammation business.industry 030206 dentistry Gingival Crevicular Fluid Red complex Gingival fluid Otorhinolaryngology 030220 oncology & carcinogenesis medicine.symptom business medicine.drug |
| Zdroj: | Oral Diseases |
| Popis: | Objectives (a) To compare levels of pro- and anti-inflammatory mediators in saliva and gingival crevicular fluid (GCF) in children with and without congenital heart defects (CHD cases and controls) and to test whether a systemic component exists in CHD cases by controlling for gingivitis and plaque scores. (b) To correlate the levels of pro- and anti-inflammatory mediators in GCF and saliva with plaque bacterial composition among CHD cases and controls. Materials and Methods Whole un-stimulated saliva and GCF samples were collected (60 CHD cases, 60 controls [Sudan]) and were analysed for levels of prostaglandin E2 (PGE2), interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α), interleukin-1ra (IL-1ra) and interleukin-10 (IL-10) levels. These levels were correlated with the previously reported levels of four red complex bacteria. Results Significantly elevated levels of PGE2 and IL-1β in GCF and IL-1β and TNF-α in saliva were detected among CHD cases compared with controls. General linear model (GLM) analyses revealed that PGE2 and IL-1β levels remained significantly higher in GCF and saliva samples, respectively, among CHD cases after controlling for gingivitis and plaque score, whereas TNF-α and IL-10 levels were significantly lower in their GCF samples. Additionally, IL-1β level was significantly positively correlated to the counts of the four red complex species in their GCF. Conclusion In addition to higher levels of some pro-inflammatory mediators in saliva and GCF corresponding to more gingivitis in CHD cases, also a systemic inflammatory component exists and is reflected in these two oral fluids. publishedVersion |
| Databáze: | OpenAIRE |
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