Interspecies comparisons of functional genetic variations and their implications in neuropsychiatry
| Autor: | David A. Collier, Martien J H Kas, Leonard C. Schalkwyk, Cigdem Gelegen |
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| Rok vydání: | 2009 |
| Předmět: |
Mice
Transgenic Nerve Tissue Proteins Computational biology Catechol O-Methyltransferase Genome Mice Cellular and Molecular Neuroscience DISC1 Genetic variation Animals Humans Copy-number variation Genetic variability Allele Genetics (clinical) Mice Knockout Psychiatry Genetics biology Brain-Derived Neurotrophic Factor Mental Disorders Genetic Variation Phenotype Mice Mutant Strains Disease Models Animal Psychiatry and Mental health biology.protein Identification (biology) |
| Zdroj: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :309-317 |
| ISSN: | 1552-485X 1552-4841 |
| Popis: | Animal studies are important for the identification and functional characterization of the biological substrates underlying complex psychiatric disorders. However, novel insights into the relationship between the genome and behavior are needed for the development of fully valid translational models. Based on the notion that in different species, the same genes may independently give rise to alleles with similar functional and phenotypic effects, either under similar selection or through similar genomic mechanisms, we propose the use of genetic validity as a tool for identifying analogous pathology between animals and human neuropsychiatric disorders. Furthermore, the identification of copy number variants which disrupt entire genes, reinforces the notion that transgenic animals, such as knockouts or knock-ins, may provide unexpectedly valid disease models for psychiatric traits. To illustrate interspecies comparison of genetic variations in relation to neurobehavioral traits, examples are provided for the BDNF, COMT, and DISC1 genes in mouse and man. We propose that alignment of individual genetic variations with endophenotypes obtained from mice and across categories of neuropsychiatric disorders will provide an important step in translational research. |
| Databáze: | OpenAIRE |
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