P4 cap modified tetrapeptidyl alpha-ketoamides as potent HCV NS3 protease inhibitors
| Autor: | Shu-Hui Chen, David X Sun, Beverly A. Heinz, Yip Yvonne Yee Mai, Lifei Liu, Alexander A. Kolykhalov, Jason Eric Lamar, Q. May Wang, Robert B. Johnson |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
chemistry.chemical_classification
Adipic acid Tetrapeptide biology Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Peptide Viral Nonstructural Proteins Biochemistry Amides chemistry.chemical_compound Enzyme chemistry Enzyme inhibitor Amide Drug Discovery biology.protein Molecular Medicine Tetrazole Protease inhibitor (pharmacology) Protease Inhibitors Molecular Biology |
| Zdroj: | Bioorganicmedicinal chemistry letters. 14(16) |
| ISSN: | 0960-894X |
| Popis: | We describe herein the design, syntheses, and biological evaluation of new series of P4 tetrazole and adipic acid, ester, amide capped tetrapeptidyl alpha-ketoamide based HCV protease inhibitors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect