Schedule dependence of the lethal effects of 6-azauridine and cytosine arabinoside on murine leukemia cells (L5178Y) in culture
| Autor: | Brenckman Wd, Fischer Ga, Chu My |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Azauridine
Time Factors Cell Survival medicine.medical_treatment Biophysics Pharmacology Biochemistry Mice chemistry.chemical_compound Tissue culture L Cells medicine Animals Neoplasm Molecular Biology Chemotherapy Lymphoblast Cytarabine Drug Synergism Cell Biology medicine.disease Virology Leukemia chemistry Antineoplastic Drugs Cytosine |
| Zdroj: | Biochemical and Biophysical Research Communications. 52:1368-1373 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(73)90652-9 |
| Popis: | The antineoplastic drugs 6-azauridine and cytosine arabinoside exhibit a supra-additive lethal effect on murine L5178Y lymphoblasts if exposure to 6-azauridine precedes exposure to cytosine arabinoside; an additive effect is seen if cytosine arabinoside precedes 6-azauridine, while a sub-additive effect is obtained when the two drugs are present simultaneously. The potentiation of the effect of cytosine arabinoside by 6-azauridine increases for 2 1 2 hours following the removal of the 6-azauridine from the culture. |
| Databáze: | OpenAIRE |
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