What do national pharmacoeconomic guidelines recommend regarding the statistical analysis of trial-based economic evaluations?
| Autor: | Judith E. Bosmans, Johanna M. van Dongen, Anita N Varga, Angela Jornada Ben, Alejandra E Guevara Morel, Maurits W. van Tulder, Mohamed El Alili, Mojdeh Khorrami |
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| Rok vydání: | 2019 |
| Předmět: |
economic evaluation
media_common.quotation_subject review Guidelines as Topic Scarcity 03 medical and health sciences 0302 clinical medicine Statistical quality Humans Pharmacology (medical) Statistical analysis Economics Pharmaceutical 030212 general & internal medicine Baseline (configuration management) Cluster analysis Health policy media_common Clinical Trials as Topic Actuarial science 030503 health policy & services Health Policy trials General Medicine Missing data Research Design Data Interpretation Statistical SDG 1 - No Poverty Economic evaluation statistical methods Pharmacoeconomic guidelines 0305 other medical science Psychology |
| Zdroj: | van Dongen, H, El Alili, M, Varga, A N, Guevara Morel, A E, Jornada Ben, A, Khorrami, M, van Tulder, M W & Bosmans, J E 2020, ' What do national pharmacoeconomic guidelines recommend regarding the statistical analysis of trial-based economic evaluations? ', Expert review of pharmacoeconomics & outcomes research, vol. 20, no. 1, pp. 27-37 . https://doi.org/10.1080/14737167.2020.1694410 van Dongen, J M, El Alili, M, Varga, A N, Guevara Morel, A E, Jornada Ben, A, Khorrami, M, van Tulder, M W & Bosmans, J E 2020, ' What do national pharmacoeconomic guidelines recommend regarding the statistical analysis of trial-based economic evaluations? ', Expert Review of Pharmacoeconomics and Outcomes Research, vol. 20, no. 1, pp. 27-37 . https://doi.org/10.1080/14737167.2020.1694410 |
| ISSN: | 1744-8379 1473-7167 |
| DOI: | 10.1080/14737167.2020.1694410 |
| Popis: | Introduction: The statistical quality of many trial-based economic evaluations is poor. When conducting trial-based economic evaluations, researchers often turn to national pharmacoeconomic guidelines for guidance. Therefore, this study reviewed which recommendations are currently given by national pharmacoeconomic guidelines on the statistical analysis of trial-based economic evaluations. Areas covered: 40 national pharmacoeconomic guidelines were identified. Data were extracted on the guidelines’ recommendations on how to deal with baseline imbalances, skewed costs, correlated costs and effects, clustering of data, longitudinal data, and missing data in trial-based economic evaluations. Four guidelines (10%) were found to include recommendations on how to deal with baseline imbalances, five (13%) on how to deal with skewed costs, and seven (18%) on how to deal with missing data. Recommendations were very general in nature and recommendations on dealing with correlated costs and effects, clustering of data, and longitudinal data were lacking. Expert opinion: Current national pharmacoeconomic guidelines provide little to no guidance on how to deal with the statistical challenges to trial-based economic evaluations. Since the use of suboptimal statistical methods may lead to biased results, and, therefore, possibly to a waste of scarce resources, national agencies are advised to include more statistical guidance in their pharmacoeconomic guidelines. |
| Databáze: | OpenAIRE |
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