Quantitative assessment of foetal exposure to trenbolone acetate, zeranol and melengestrol acetate, following maternal dosing in rabbits
| Autor: | H. H. D. Meyer, N E Skakkebaek, A. Daxenberger, Iris G. Lange, E. Rajpert-De Meyts, D. N. R. Veeramachaneni |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Meat Time Factors Placenta Health Toxicology and Mutagenesis Enzyme-Linked Immunosorbent Assay Gestational Age Biology Toxicology Biochemistry Melengestrol acetate chemistry.chemical_compound Anabolic Agents Sex Factors Trenbolone Pregnancy Internal medicine medicine Zeranol Animals Testosterone Estrogens Non-Steroidal Glucocorticoids Maternal-Fetal Exchange Melengestrol Acetate Chromatography High Pressure Liquid Pharmacology Fetus Abnormalities Drug-Induced General Medicine Endocrinology Liver chemistry Endocrine disruptor Melengestrol Toxicity Pregnancy Animal Gestation Female Rabbits Trenbolone Acetate medicine.drug |
| Zdroj: | Xenobiotica. 32:641-651 |
| ISSN: | 1366-5928 0049-8254 |
| Popis: | 1. Residues of commonly used growth-promoting agents found in animal meat can be hormonally active and they have been implicated as possible endocrine disruptors in man. Although these compounds could be potentially detrimental to the developing foetus, it is not clear whether and to what extent they pass through placental barrier. 2. This issue was addressed using the rabbit as an animal model. Pregnant rabbits were treated with trenbolone acetate, zeranol or melengestrol acetate beginning at gestation day 14. Levels of active substances in plasma were screened by means of specific ELISA systems. The residues of parent compounds and their metabolites were quantified in maternal and foetal tissues on gestation day 27 using validated, sensitive HPLC/ELISA methods. 3. All three compounds crossed the placental barrier and were detectable in foetal tissues. The extent of tissue concentration varied depending on the compound and tissue analysed. Gender differences were observed in some instances. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|