Association of Human Leukocyte Antigen Alleles and Hypersensitivity of Efavirenz/Nevirapine in HIV-Infected Chinese Patients

Autor:	Xiao-Yan Zhou, Chong-Xi Li, Jian-Bo Zhang, Jun-Ting Tang, Xi Yang, Rowida A. Albarmaqi, Yu-Ye Li, Yi-Qun Kuang
Rok vydání:	2022
Předmět:	Infectious Diseases Virology Immunology
Zdroj:	AIDS Research and Human Retroviruses. 38:884-889
ISSN:	1931-8405 0889-2229
DOI:	10.1089/aid.2022.0027
Popis:	To examine the association between human leukocyte antigen (HLA) and nevirapine (NVP)- and efavirenz (EFV)-induced cutaneous adverse reactions in human immunodeficiency virus (HIV) patients, we conducted a case-control study at our center consisting of 96 patients. Patients were further assigned based on the occurrence of cutaneous adverse events and the drugs involved. All patients were subjected to next generation sequencing (NGS)-based screening with focus on HLA phenotype, including the presence of HLA-B, HLA-C, and HLA-DRB1. Our data indicated that the HLA-C*01:02:01 allele presence was observed in 47.4% (18/38) of patients in the EFV-hypersensitivity group compared with 18.9% (7/30) in the control group [odds ratio (OR) = 5.837; 95% confidence interval (CI) = 1.727-19.722
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c23a51867da8770515b9b37231b7814 https://doi.org/10.1089/aid.2022.0027 Zobrazit plný text záznamu