Predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease
| Autor: | Kun Shi, Xian-Min Wang, Yizhou Wen, Mei Jin, Tingting Chen, Yaheng Lu, Jimei Xi, Yong-Hong Guo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Brachial Artery Coronary artery abnormality Flow mediated dilation Diseases Coronary Artery Disease 030204 cardiovascular system & hematology 0302 clinical medicine Medicine Prospective Studies Brachial artery Child Multidisciplinary Predictive value medicine.anatomical_structure Child Preschool Blood Circulation Cardiology cardiovascular system Female Artery medicine.medical_specialty Adolescent Fever Science Mucocutaneous Lymph Node Syndrome Article 03 medical and health sciences Aneurysm Medical research Predictive Value of Tests 030225 pediatrics Internal medicine medicine.artery Humans cardiovascular diseases business.industry Health care Infant Newborn Infant medicine.disease Acute stage ROC Curve Case-Control Studies Kawasaki disease business |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Coronary artery abnormalities (CAAs) are a severe complication of Kawasaki disease (KD) that may lead to cardiovascular events. Given the evidence that brachial artery flow-mediated dilation (FMD) decreases in children after the onset of KD, we hypothesized that it could be an early marker of CAA development in the acute stage and investigated its relationship with variation in the coronary artery diameter. A total of 326 sex- and age-matched children were enrolled, including 120 with KD, 109 febrile children and 97 healthy controls. In this study, FMD was significantly decreased in the KD group compared with the febrile and healthy groups. FMD was lower in the CAA group than in the no coronary artery abnormality group. The comparison of FMD showed an obvious difference among the CAA subgroups. The FMD in the coronary aneurysm (CA) group showed a strong negative correlation with the pretreatment maximum coronary artery Z-score (preZmax). While preZmax was 2.5, the receiver operating characteristic curve indicated an optimal cutoff point of 3.44% for FMD. FMD ≤ 3.44% could be considered as a signal of coronary lesions in acute stage of KD. |
| Databáze: | OpenAIRE |
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