Predictive factors for a single successful cytapheresis session during the first mobilisation
| Autor: | Stéphane Cheze, Hyacinthe Johnson-Ansah, A. Batho, Oumedaly Reman, C. Fruchart, Sylvain Chantepie, Margaret Macro, V. Lefevre, Jean-Jacques Parienti, Anne-Claire Gac, Khaled Benabed |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Transplantation Conditioning Lymphoma Cd34 cells Antigens CD34 Transplantation Autologous Cohort Studies Young Adult Predictive Value of Tests Humans Medicine Multiple myeloma Aged business.industry Plerixafor Hematopoietic Stem Cell Transplantation Hematology Middle Aged Prognosis medicine.disease Hematopoietic Stem Cell Mobilization Surgery Stem cell mobilisation Cytapheresis Treatment Outcome Apheresis Oncology Female Stem cell Multiple Myeloma business medicine.drug |
| Zdroj: | Leukemia Research. 38:1020-1024 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2014.05.001 |
| Popis: | To avoid repeated apheresis, the objective of this study was to analyse the predictive factors for a single successful cytapheresis during the first mobilisation. The pre-collection characteristics of 170 lymphoma and 95 myeloma patients were analysed. Among 60 lymphoma patients who had less than 30 CD34 cells/mm(3) the day before the first apheresis, an increase in the CD34 cell count between Day -1 and Day 1 was predictive of first stem cell mobilisation success, with a sensitivity of 100% if the Day 1 was higher than 30/mm(3) (10/60 patients). Success rate of obtaining an appropriate number of stem cells in one apheresis was 120 among 170 patients. |
| Databáze: | OpenAIRE |
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