Time-Dependent Differences in the Influence of Perivascular Adipose Tissue on Vasomotor Functions in Metabolic Syndrome

Autor: Satomi Kagota, John J. McGuire, Saki Iwata, Kana Maruyama, Kazumasa Shinozuka
Rok vydání: 2017
Předmět:
Male
Nitroprusside
0301 basic medicine
medicine.medical_specialty
Time Factors
Vasodilator Agents
Endocrinology
Diabetes and Metabolism
Adipose tissue
Vasodilation
In Vitro Techniques
030204 cardiovascular system & hematology
Nitric Oxide
Rats
Inbred WKY
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Rats
Inbred SHR
Internal medicine
Paracrine Communication
Internal Medicine
medicine
Animals
Cyclic GMP
Mesenteric arteries
Crosses
Genetic
Metabolic Syndrome
Dose-Response Relationship
Drug
Vasomotor
business.industry
Organ bath
medicine.disease
Acetylcholine
Mesenteric Arteries
Rats
Zucker
Disease Models
Animal
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Adipose Tissue
chemistry
Endothelium
Vascular
Metabolic syndrome
business
medicine.drug
Zdroj: Metabolic Syndrome and Related Disorders. 15:233-239
ISSN: 1557-8518
1540-4196
Popis: Metabolic syndrome (MetS) facilitates the development of cardiovascular disease due to atherosclerosis, which is accelerated by defects of the vascular endothelium. Vascular dysfunction in response to nitric oxide (NO) occurs in the mesenteric arteries of an animal model of MetS, SHRSP.Z-LeprTo determine the effects of PVAT on vasodilators in SHRSP.ZF and control Wistar-Kyoto (WKY) rats, we used organ bath bioassay techniques to assay acetylcholine and nitroprusside-induced relaxations of isolated mesenteric arterial ring preparations with PVAT intact or removed.A PVAT-mediated enhancement of relaxations induced by acetylcholine and nitroprusside occurred in SHRSP.ZF at 20 weeks of age, but not at 10 and 30 weeks, and did not occur in WKY. Furthermore, the enhancing effects of PVAT from SHRSP.ZF at 20 weeks could not be substituted by replacement with PVAT from either WKY or 30-week-old SHRSP.ZF, was inhibited by NO synthase inhibitor, and abolished by removal of the arteries' endothelium. Cyclic guanosine monophosphate (cGMP) accumulation elicited by nitroprusside was higher in SHRSP.ZF arteries with PVAT than arteries without PVAT at 20 weeks, but the enhancement of cGMP accumulation did not occur at 30 weeks.PVAT may regulate arterial tone by releasing diffusible vasorelaxing factor(s), which, through endothelium-derived NO production, compensates for impaired vasodilations at early stages of MetS.
Databáze: OpenAIRE
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