The trajectory of apathy after deep brain stimulation: From pre-surgery to 6 months post-surgery in Parkinson’s disease
| Autor: | Laura B. Zahodne, Michael Marsiske, Dawn Bowers, Lindsey Kirsch-Darrow, Kelly D. Foote, Michael S. Okun |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Levodopa medicine.medical_specialty Deep brain stimulation Parkinson's disease Deep Brain Stimulation medicine.medical_treatment Apathy Neuropsychological Tests Globus Pallidus Article Predictive Value of Tests Subthalamic Nucleus medicine Humans Psychiatry Depression (differential diagnoses) Aged Psychiatric Status Rating Scales Chi-Square Distribution Parkinson Disease Middle Aged medicine.disease nervous system diseases Subthalamic nucleus Treatment Outcome Globus pallidus nervous system Neurology Anesthesia Laterality Linear Models Female Neurology (clinical) Geriatrics and Gerontology medicine.symptom Psychology medicine.drug |
| Zdroj: | Parkinsonism & Related Disorders. 17:182-188 |
| ISSN: | 1353-8020 |
| DOI: | 10.1016/j.parkreldis.2010.12.011 |
| Popis: | Deep brain stimulation (DBS) has been associated with increased apathy in patients with PD, yet studies lack longitudinal data and have not assessed differences between sites of implantation (i.e. STN versus GPi). We assessed apathy prior to surgery and 6 months post-surgery using a longitudinal designe–latent growth curve modeling. We hypothesized that apathy would increase post-surgery, and be related to subthalamic nucleus (versus globus pallidus interna) implantation. Forty-eight PD patients underwent unilateral surgery to either GPi or STN and completed the Apathy Scale prior to surgery and 2, 4, and 6 months post-surgery. Forty-eight matched PD controls completed the Apathy Scale at a 6-month interval. Results indicated apathy increased linearly from pre- to 6-months post-DBS by .66 points bi-monthly, while apathy in the control group did not change. There was no relationship between apathy and DBS site. Higher baseline depression was associated with higher baseline apathy, but not with change in apathy. Middle-aged adults ( |
| Databáze: | OpenAIRE |
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