Antidiabetic effects of ethanol extract of Uromastyx hardwickii Smith (Agamidae) skin on streptozotocin-induced diabetes mellitus in mice
| Autor: | Waqas A. Shams, Samuel O. Onoja, Gauher Rehman, Saif U. Islam, Khurshaid Khan, Muhmmad Ibrar, Saima B. Sia, Saba G. Ayaz, Sajid Ali, Muhammad Israr, Aziz Ullah, Dawood Safi |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Tropical Journal of Pharmaceutical Research; Vol. 20 No. 3 (2021); 627-632 |
| ISSN: | 1596-9827 1596-5996 |
| Popis: | Purpose: To investigate the in vivo hypoglycemic potential of the ethanol extract of Uromastyx hardwickii skin (EEUHS). Methods: Streptozotocin-induced diabetic mice received graded doses (100 and 200 mg/kg) of EEUHS for oral glucose tolerance and hypoglycemic test. The effects of EEUHS on body weight gain, urea, creatinine, cholesterol and hemoglobin concentration were also investigated. Result: The blood glucose concentrations of the EEUHS-treated groups were diminished (p < 0.05) relative to the diabetic control group. The urea, creatinine and cholesterol levels of the EEUHS-treated groups were lower (p < 0.05), but their hemoglobin concentrations were higher (p < 0.05) relative to the diabetic control group. Conclusion: The EEUHS elicits hypoglycemic effects and ameliorates complications of diabetes mellitus in streptozotocin-induced diabetic mice. This suggests that EEUHS can potentially be developed for the management of diabetic patients. |
| Databáze: | OpenAIRE |
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