Synthesis of saturated imidazolidin[1,5-a]- and thiazolidin[3,4-a]perhydroquinoxalin-4-one and imidazolidin[1,5-a]piperazin-4-one derivatives : ring contraction of perhydroquinoxalin-4-one to perhydrobenzimidazolin-2-one
| Autor: | Jacek Grochowski, Robert Socha, Barbara Zaleska, Marcin Karelus, Paweł Serda |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Thiophosgene
Contraction (grammar) Stereochemistry imidazolidin[1 5-a]piperazine Organic Chemistry General Medicine Crystal structure fused saturated hetorocycles Medicinal chemistry Catalysis Synchrotron law.invention chemistry.chemical_compound imidazolidin[1 5-a]perhydroquinoxaline chemistry law Diiodomethane thiazolidin[3 4-a]perhydroquinoxaline |
| Popis: | Saturated fused systems such as imidazolidin[ 1,5-a]- and thiazolidin[3,4-a]perhydroquinoxalin-4-one as well as imidazolidin[1,5-a]piperazin-4-one derivatives were prepared by cyclocondensation reactions of appropriate perhydroquinoxalin-3-one and piperazin-3-one derivatives with diiodomethane and thiophosgene. An unusual ring contraction of perhydroquinoxalin-3-one derivatives to perhydrobenzimidazolidin-2-one derivatives by reaction with 1,2-dibromoethane was proved using crystal structure analysis with synchrotron and laboratory radiation sources. |
| Databáze: | OpenAIRE |
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