Hepatocellular carcinoma occurring in a Crohn’s disease patient
| Autor: | Mikiko Takikita-Suzuki, Yoshihide Fujiyama, Yoshimasa Kurumi, Shigeyuki Naka, Hisanori Shiomi, Hidetoshi Okabe, Yasuharu Saito, Machiko Hotta, Tomoyuki Tsujikawa, Tamio Nakahara, Tohru Tani, Fumiyoshi Kojima, Mitsuaki Ishida, Akira Andoh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Pathology Cirrhosis Liver tumor Carcinoma Hepatocellular Medication history Azathioprine Case Report Gastroenterology Primary sclerosing cholangitis Crohn Disease Internal medicine medicine Humans Crohn's disease business.industry Liver Neoplasms General Medicine medicine.disease digestive system diseases Hepatocellular carcinoma Histopathology business Immunosuppressive Agents medicine.drug |
| Popis: | We report a case of hepatocellular carcinoma (HCC) occurring in a patient with Crohn's disease (CD) without chronic hepatitis or liver cirrhosis, and review the clinicopathological features of HCC in CD patients. A 37-year-old Japanese man with an 8-year history of CD and a medication history of azathioprine underwent resection of a liver tumor. The histopathology of the liver tumor was pseudoglandular type HCC. In the non-neoplastic liver, focal hepatocyte glycogenosis (FHG) was observed, however, there was no evidence of liver cirrhosis or primary sclerosing cholangitis. Only nine cases of HCC in CD patients have been reported previously in the English-language literature. Eight of 10 cases (including the present case) had received azathioprine treatment, and four of these cases also showed FHG, which is considered a preneoplastic liver lesion, within the non-neoplastic liver. Although the precise mechanism of the development of HCC in CD patients is controversial, these results suggest that azathioprine therapy and FHG in the non-neoplastic liver contribute to the development of HCC. These findings also indicate that it is important to survey CD patients treated with prolonged azathioprine therapy for potential liver tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|