Constraint of Base Pairing on HDV Genome Evolution

Autor:	Hiroyuki Toh, Ryoji Kiyohara, Saki Nagata
Rok vydání:	2021
Předmět:	Genome evolution Base pair Biology Microbiology Genome Virus Article Evolution Molecular hepatitis delta virus Circular RNA hepatitis delta antigen Virology one-sample Wilcoxon test Humans Nucleotide base pairing Protein secondary structure Genetics chemistry.chemical_classification QR1-502 Hepatitis D Constraint (information theory) Infectious Diseases chemistry RNA Viral
Zdroj:	Viruses Viruses, Vol 13, Iss 2350, p 2350 (2021) Viruses; Volume 13; Issue 12; Pages: 2350
ISSN:	1999-4915
Popis:	The hepatitis delta virus is a single-stranded circular RNA virus, which is characterized by high self-complementarity. About 70% of the genome sequences can form base-pairs with internal nucleotides. There are many studies on the evolution of the hepatitis delta virus. However, the secondary structure has not been taken into account in these studies. In this study, we developed a method to examine the effect of base pairing as a constraint on the nucleotide substitutions during the evolution of the hepatitis delta virus. The method revealed that the base pairing can reduce the evolutionary rate in the non-coding region of the virus. In addition, it is suggested that the non-coding nucleotides without base pairing may be under some constraint, and that the intensity of the constraint is weaker than that by the base pairing but stronger than that on the synonymous site.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1a773bee5f531d88f94dafa4d69117 https://pubmed.ncbi.nlm.nih.gov/34960619 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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