The Role of Complement-Derived Chemotactic Factors in Lung Injury Induced by Preformed Immune Complexes
| Autor: | Tetsuo Sato, Heiichi Yano, Masahiko Tanoue, Yasuyuki Yoshizawa, Yuji Kimula, Kiyomi Miyamoto |
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| Rok vydání: | 1993 |
| Předmět: |
Guinea Pigs
Immunology Inflammation Antigen-Antibody Complex Lung injury Immune system medicine Animals Immunology and Allergy Lung Chemotactic Factors medicine.diagnostic_test business.industry Proteins Chemotaxis Complement System Proteins General Medicine respiratory system medicine.disease Immune complex Bronchoalveolar lavage medicine.anatomical_structure Female Rabbits medicine.symptom business Bronchoalveolar Lavage Fluid Hypersensitivity pneumonitis Alveolitis Extrinsic Allergic |
| Zdroj: | International Archives of Allergy and Immunology. 101:47-51 |
| ISSN: | 1423-0097 1018-2438 |
| Popis: | Our previous studies have suggested a role for complement fragments presumably activated by immune complexes in patients with hypersensitivity pneumonitis. The present study has shown that circulating complement depletion by cobra venom factor resulted in the reduction in severity of immune-complex-mediated pulmonary inflammation. The activity of chemotactic factors for neutrophils generated in bronchoalveolar lavage fluids in complement-depleted animals was significantly diminished to 61.2% compared to the undepleted animals. In addition, reduced activity of chemotactic factors resulted in a marked reduction of accumulation of neutrophils in bronchoalveolar lavage fluids indicating that chemotactic factors play an important role in the sequestration of neutrophils on the alveolar side of the lung. In conclusion, chemotactic factors in bronchoalveolar lavage fluids which preceded the accumulation of polymorphonuclear cells are partially derived from complement. |
| Databáze: | OpenAIRE |
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