Air pollution and activation of implantable cardioverter defibrillators in London
Autor: | H. Ross Anderson, Adam Timmis, Shakoor Hajat, Ben Armstrong, Roy M. Harrison, Jan D. Poloniecki, Vivienne Monk, Paul Wilkinson |
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Rok vydání: | 2010 |
Předmět: |
Male
medicine.medical_specialty Ozone Particle number Epidemiology Air pollution Electric Countershock Black smoke medicine.disease_cause chemistry.chemical_compound Internal medicine Air Pollution London Medicine Humans Aged Pollutant Cross-Over Studies business.industry Odds ratio Particulates Middle Aged Confidence interval Defibrillators Implantable chemistry Cardiology Female business |
Zdroj: | Epidemiology (Cambridge, Mass.). 21(3) |
ISSN: | 1531-5487 |
Popis: | Background Air pollution may increase the incidence of ventricular cardiac arrhythmias. We investigated this in patients with implantable cardioverter defibrillators attending London clinics. Method We explored associations between dates of activation of defibrillators and daily concentrations of various metrics of particulate matter and of pollutant gases at lags from 0 to 5 days, using a fixed-stratum case-crossover analysis controlling for confounding factors. Results Over an average of 1200 days of observation, 705 patients experienced 5462 activation days. Of 11 pollutants considered, we found positive associations with particle sulfate, particulate matter with aerodynamic diameter less than 10 microm and less than 2.5 microm, ozone, and sulfur dioxide. Only the association for particle sulfate was not easily explainable by chance (for 1 microg/m, lag 0-1 day, odds ratio = 1.025 [95% confidence interval = 1.003 to 1.047]). There was little or no evidence of associations with markers of primary vehicle emissions (particle number concentration, black smoke, nitrogen oxides, and carbon monoxide). There was little evidence of interactions with clinical factors such as ischemic heart disease, frequency of activation, or cardiac drugs. Conclusion Overall there was little evidence of an association between air pollution and activation of implantable cardioverter defibrillators. The pollutants with positive associations tended to be those of secondary origin with a regional distribution, rather than primary pollutants emitted from transport sources. |
Databáze: | OpenAIRE |
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