Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial

Autor: Hiroshi Kawahara, Tomoko Mizukaki, Megumi Suzuki, Nobuhiro Hanada, Mamiko Yamashita, Rumi Wakiyama, Ken Tateno, Akiko Imamura, Meu Ariyoshi, Tsutomu Sato, Ayako Okada, Takatoshi Murata, Hiromi Uematsu, Ryoko Otsuka, Masayuki Suzuki, Miki Kosaka, Hitomi Aoyagi, Khairul Matin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Teeth
Brachial Artery
Mandible
Vascular Medicine
Gastroenterology
law.invention
Geographical Locations
chemistry.chemical_compound
Medical Conditions
Oral Diseases
Randomized controlled trial
Japan
law
Medicine and Health Sciences
Maxilla
Stage (cooking)
Brachial artery
Multidisciplinary
Arteries
Middle Aged
Treatment Outcome
Medicine
Female
Anatomy
medicine.symptom
Research Article
Dilatation
Pathologic
Adult
medicine.medical_specialty
Drug Research and Development
Asia
Patients
Science
Oral Medicine
Bleeding on probing
Hemorrhage
Research and Analysis Methods
Arginine
Young Adult
Signs and Symptoms
medicine.artery
Internal medicine
medicine
Humans
Clinical Trials
In patient
Periodontal Diseases
Aged
Pharmacology
business.industry
Biology and Life Sciences
Atherosclerosis
Oral Hygiene
Randomized Controlled Trials
Confidence interval
Health Care
Clinical trial
Self Care
Jaw
chemistry
People and Places
Cardiovascular Anatomy
Blood Vessels
Endothelium
Vascular
Clinical Medicine
Asymmetric dimethylarginine
business
Digestive System
Head
Biomarkers
Follow-Up Studies
Zdroj: PLoS ONE, Vol 16, Iss 9, p e0257247 (2021)
PLoS ONE
ISSN: 1932-6203
Popis: Although a significant association between periodontal disease and atherosclerotic cardiovascular disease has been reported, their cause-to-effect relationship remains controversial. This randomized controlled clinical trial aimed to investigate the effect of advanced self-care on atherosclerotic cardiovascular disease-related vascular function markers flow-mediated brachial artery dilatation (FMD) and serum asymmetric dimethylarginine (ADMA) level in patients with early-stage periodontal disease. The study was designed as a parallel group, 3-month follow-up, open-label, randomized controlled trial. The control group received standard care for periodontal diseases, whereas the test group additionally applied disinfectant using a custom-fabricated prescription tray for advanced self-care twice a day. Overall, 110 patients provided data for FMD and serum ADMA level. No significant improvements in FMD were observed in the control (mean increase, −0.1%; 95% confidence interval [CI], −1.0–0.8; P = 0.805) or test (mean increase, −0.3%; 95% CI, −1.1–0.4; P = 0.398) group. No significant changes in serum ADMA levels were observed (mean reduction, 0.01 μmol/L; 95% CI, −0.00–0.02; P = 0.366 and mean reduction, 0.00 μmol/L; 95% CI, −0.01–0.01; P = 0.349, respectively). No significant between-group differences were found in FMD (mean difference, −0.2%; 95% CI, −1.4–0.9; p = 0.708) or serum ADMA levels (mean difference, 0.01 nmol/L; 95% CI, −0.00–0.03; p = 0.122). Significant improvements in the average probing pocket depth were observed in the control and test groups. The bleeding on probing score in the test group was significantly reduced, while that in the control group was reduced, although not significantly. Periodontal care for a 3-month duration did not provide better endothelial function although improvements of periodontal status in patients with early-stage periodontal diseases. This trial is registered in UMIN Clinical Trials Registry (www.umin.ac.jp/ctr/; ID: UMIN000023395).
Databáze: OpenAIRE
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