Comprehensive two-dimensional gas chromatography with mass spectrometry: an advanced bioanalytical technique for clinical metabolomics studies
| Autor: | Atiqah Zaid, Mohammad Sharif Khan, Dandan Yan, Philip J. Marriott, Yong Foo Wong |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | The Analyst. 147:3974-3992 |
| ISSN: | 1364-5528 0003-2654 |
| Popis: | The detection of human-derived metabolites as potential diagnostic biomarkers of genetic disorders, metabolic diseases, systemic diseases, and infectious diseases has been much studied in recent years, especially as technical capabilities improve, and statistical procedures are increasingly able to tease critical chemical attributes from complex data sets. Given the complex distribution of human biological matrices, the characterization and/or identification of these chemical entities is technically challenging, and is often confounded by incomplete chromatographic resolution or insufficient discriminatory power of the mass spectrometry (MS) domain. Recently, comprehensive two-dimensional gas chromatography (GC×GC) has evolved into a mature higher separation order technique that offers unprecedented resolving power, which in turn can greatly advantage clinical metabolomics studies |
| Databáze: | OpenAIRE |
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