Electroconvulsive therapy with a memory reactivation intervention for post-traumatic stress disorder: A randomized controlled trial

Autor: Albert H.C. Wong, Moshe Isserles, Kristina M. Gicas, Victor M. Tang, Suvercha Pasricha, Yuan Chung, Kathleen Trought, Daphne Voineskos, Zafiris J. Daskalakis, Daniel M. Blumberger, Yuliya Knyahnytska, Mari Kozak, Young Zhou, Sheena A. Josselyn
Rok vydání: 2021
Předmět:
Adult
medicine.medical_specialty
medicine.medical_treatment
Biophysics
Neurosciences. Biological psychiatry. Neuropsychiatry
Traumatic memories
behavioral disciplines and activities
050105 experimental psychology
Time
law.invention
Stress Disorders
Post-Traumatic
03 medical and health sciences
0302 clinical medicine
Electroconvulsive therapy
Randomized controlled trial
Heart Rate
Memory
law
Intervention (counseling)
mental disorders
Heart rate
Humans
Medicine
Imagery
0501 psychology and cognitive sciences
Depression (differential diagnoses)
Post-traumatic stress disorder
business.industry
General Neuroscience
05 social sciences
Traumatic stress
Reconsolidation
Stress disorders
Treatment Outcome
Physical therapy
Female
Memory consolidation
Neurology (clinical)
business
030217 neurology & neurosurgery
RC321-571
Zdroj: Brain Stimulation, Vol 14, Iss 3, Pp 635-642 (2021)
ISSN: 1935-861X
DOI: 10.1016/j.brs.2021.03.015
Popis: Background Post-traumatic Stress Disorder (PTSD) often does not respond to available treatments. Memories are vulnerable to disruption during reconsolidation, and electroconvulsive therapy (ECT) has amnestic effects Objective/hypothesis To test the use of ECT to disrupt the reconsolidation of traumatic memories as a potential treatment for PTSD Methods Participants were adults from the civilian population and were referred for ECT treatment for severe depression with comorbid PTSD symptoms. Twenty-eight participants were randomly assigned to reactivation of a traumatic or non-traumatic memory using audio script driven imagery prior to each ECT treatment. Primary outcomes were change in scores on the Modified PTSD Symptom Scale - Self Report (MPSS-SR) and the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5). Secondary outcomes included a comparison of the change in heart rate while listening to the script Results Twenty-five female patients who completed a post-ECT assessment were included in the analysis. No significant group differences were found in the MPSS-SR or CAPS-5 scores from pre-ECT to post-ECT or 3-month follow-ups. However, both groups improved at post-ECT and 3-month follow up. Partial eta squared estimates of effect size showed large effect sizes for all outcomes (η2 > 0.13). Changes in heart rate were not significantly different between groups or over time Conclusions ECT paired with pre-treatment traumatic memory reactivation was not more effective for treating PTSD symptoms than ECT with non-traumatic memory reactivation. While our primary hypothesis was not supported, our data provides further support for the efficacy of ECT for improving symptoms of PTSD with comorbid depression. ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04027452 . Identifier NCT04027452.
Databáze: OpenAIRE
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