Hypericum Extract and Hyperforin: Memory-Enhancing Properties in Rodents
| Autor: | S. Germane, V. Klusa, Shyam Sunder Chatterjee, Michael Nöldner |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Stereochemistry Scopolamine Amnesia Muscarinic Antagonists Phloroglucinol Pharmacology Avoidance response Bridged Bicyclo Compounds Mice chemistry.chemical_compound Memory Oral administration Avoidance Learning Animals Medicine Pharmacology (medical) Rats Wistar Mice Inbred BALB C Behavior Animal biology Plant Extracts Terpenes business.industry Hypericum perforatum General Medicine biology.organism_classification Effective dose (pharmacology) Antidepressive Agents Rats Psychiatry and Mental health Hyperforin chemistry Antidepressant medicine.symptom business Hypericum |
| Zdroj: | Pharmacopsychiatry. 34:61-69 |
| ISSN: | 1439-0795 0176-3679 |
| DOI: | 10.1055/s-2001-15451 |
| Popis: | Effects of a Hypericum extract in therapeutic use and hyperforin sodium salt were evaluated in rat and mouse avoidance tests. In a conditioned avoidance response (CAR) test on the rat, oral daily administration of hyperforin (1.25 mg/kg/day) or of the extract (50 mg/kg/day) before the training sessions considerably improved learning ability from the second day onwards until the day 7. In addition, the memory of the learned responses acquired during 7 consecutive days of administration and training was largely retained even after 9 days without further treatment or training. The observations made using different doses indicate that these learning-facilitating and/or memory-consolidating effects by the agents follow inverse U-shaped dose-response curves in dose ranges lower than (for hyperforin) or equal to (for Hypericum extract) their effective dose in the behavioral despair test for antidepressants. In a passive avoidance response test on the mouse, a single oral dose (1.25 mg/kg) of hyperforin not only improved memory acquisition and consolidation, but also almost completely reversed scopolamine-induced amnesia. The single Hypericum extract dose tested (25 mg/kg) did not reveal any significant effects in the passive avoidance response (PAR) test on the mouse. These observations suggest that the Hypericum extract could be a novel type of antidepressant with memory enhancing properties, and indicate that hyperforin is involved in its cognitive effects. Pure hyperforin seems to be a more potent antidementia agent than an antidepressant. |
| Databáze: | OpenAIRE |
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